Prep pan and oven. Position a rack in the center of your oven and preheat the oven to 350°F. Lightly grease a 9 inch by 5 inch loaf pan. I like to line mine with parchment paper as well and grease lightly again.
Prepare cream cheese filling. In a small bowl, with an electric mixer (or if the cream cheese mixture is soft enough you can use a wooden spoon.) Beat together the egg, vanilla, cream cheese and sugar until smooth. 1 large egg 1 ½ teaspoons vanilla extract 4 ounces brick-style cream cheese ¼ cup (50 g) granulated sugar
Combine Dry Ingredients. In a large mixing bowl, whisk together the flour, baking powder, baking soda, salt, pumpkin pie spice, cinnamon, and nutmeg. 3 tablespoons (23 g) all-purpose flour 1 ½ cups (180 g) all-purpose flour ¼ teaspoon baking powder 1 teaspoons baking soda ¾ teaspoons salt 1 teaspoon pumpkin pie spice 2 teaspoons cinnamon ½ teaspoon nutmeg
Combine wet ingredients. In a second mixing bowl, whisk together the oil, sugars, eggs, vanilla, pumpkin, and water. ½ cup (120 ml) vegetable oil ⅔ cups (134 g) granulated sugar ⅔ cups (142 g) light brown sugar 2 large eggs 2 teaspoons vanilla extract 1 cup (227 g) pumpkin puree ⅓ cup (80 ml) water
Combine wet and dry ingredients. Make a well in the center of your dry ingredients and pour in the liquid ingredients. With a spatula, stir to combine until the last of the flour has been mixed in. Stop mixing at this point to avoid overmixing.
Add to pan. Pour about 2/3 of the batter into the prepared loaf pan. Spoon the cream cheese filling into the loaf pan. Spread to cover the pumpkin batter carefully with a spatula, spreading to the corners. Top with the remaining pumpkin batter. (It's ok if some cheesecake batter is showing, but try to cover it as best you can!)
Bake the bread. Bake the bread for 60-70 minutes, or until a cake tester or toothpick inserted in the center of the loaf comes out clean; and that same tester inserted about 1/2" into the top of the loaf doesn't encounter any totally unbaked batter. Avoid the cream cheese filling layer. You should see moist crumbs, not raw batter. Mine was perfect at 60 minutes, so begin checking your bread at 60 minutes, but every oven is different so you may need additional time.
Cool the bread. Remove the bread from the oven, and cool it on a rack in the pan for 10 minutes. Remove from the pan and continue to cool. When it's completely cool, wrap it well in plastic wrap, and store it overnight before serving for best texture.